Contents

• Symposium Wrap-up
• Symposium Wrap-up Part 1
• Symposium Wrap-up Part 2
• Symposium Wrap-up Part 3
• Symposium Wrap-up Part 4

This is part 2 in our series of 2018 Symposium Wrap-up posts for our symposium and workshop, Genome Editing – Putting Together the Pieces.

In this post, we’ll dive into the details of how gene editing is done.

Reducing Off-Target Effects

One potential problem with gene editing is off-target genetic changes. This is more of a problem for use of gene editing in human medicine than in agriculture. Off-target effects also need to be considered in context.

Editing the Editors

As with other types of genetic engineering, careful selection of genetic elements and careful configuration of the construct will improve success.

Alterations of CRISPR-Cas allow researchers to reduce any off-target changes and to induce deletions or insertions at specific sites in a genome.

CRISPR targets can be combined to edit multiple genes at once.

Part 3 in our series of 2018 Symposium Wrap-up posts will discuss intellectual property protection and regulation of gene editing.